Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes
نویسندگان
چکیده
منابع مشابه
Red Queen Processes Drive Positive Selection on Major Histocompatibility Complex (MHC) Genes
Major Histocompatibility Complex (MHC) genes code for proteins involved in the incitation of the adaptive immune response in vertebrates, which is achieved through binding oligopeptides (antigens) of pathogenic origin. Across vertebrate species, substitutions of amino acids at sites responsible for the specificity of antigen binding (ABS) are positively selected. This is attributed to pathogen-...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2015
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1004627